The general mode of translation inhibition by macrolide antibiotics
نویسندگان
چکیده
منابع مشابه
The general mode of translation inhibition by macrolide antibiotics.
Macrolides are clinically important antibiotics thought to inhibit bacterial growth by impeding the passage of newly synthesized polypeptides through the nascent peptide exit tunnel of the bacterial ribosome. Recent data challenged this view by showing that macrolide antibiotics can differentially affect synthesis of individual proteins. To understand the general mechanism of macrolide action, ...
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Translation arrest directed by nascent peptides and small cofactors controls expression of important bacterial and eukaryotic genes, including antibiotic resistance genes, activated by binding of macrolide drugs to the ribosome. Previous studies suggested that specific interactions between the nascent peptide and the antibiotic in the ribosomal exit tunnel play a central role in triggering ribo...
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The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
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Macrolide antibiotics (MAs) have a wide spectrum of activities against Gram-positive bacteria, but they have also been proposed as anticancer drugs for multiple tumor types. On these bases, clinical trials have been started, and their results evidenced clinical benefits. MAs have also been tested in hematologic malignancies, alone or in combination with chemotherapeutic drugs or tyrosine kinase...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1417334111